Using AI to Understand and Make Use of the Genetic Roots of Obesity

This week, we announced a breakthrough partnership applying artificial intelligence to the study of genetic variants associated with obesity. Rare metabolic syndromes cause excessive weight gain in some patients. These conditions are very difficult to treat and lead to related health risks. Now, WuXi NextCODE is working with Rhythm Pharmaceuticals to use AI to help advance the development of drugs to treat such patients.

We’re excited to be doing this work because several key genes are known in the MC4R pathway, which helps regulate weight by increasing energy expenditure and reducing appetite. We’re now working with Rhythm to determine which of these variants correlate with the greatest impact on risk of developing obesity through this pathway.

This is one of the frontiers of rare disease research, and we hope to make rapid progress with our novel AI tools, including our proprietary DeepCODESM algorithm for variant scoring. Learn more about this intriguing research here.